C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers(Article)


Journal Article

The lupin alkaloid sparteine is a well-known chiral diamine with a range of applications in asymmetric synthesis, as well as a blocker of voltage-gated sodium channels (VGSCs). However, there is only scarce information on the VGSC-blocking activity of sparteine derivatives where the structure of the parent alkaloid is retained. Building on the recent renewed availability of sparteine and derivatives we report herein how modification of sparteine at position 2 produces irreversible blockers of VGSCs. These compounds could be clinically envisaged as long-lasting local anesthetics. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

V.S. Gawali

M. Drescher

T. Knott

O. Scheel

J. Kudolo

H. Kählig

U. Hochenegg

A. Roller

H. Todt

N. Maulide


Year of publication: 2017


ISSN: 18607179


DOI: 10.1002/cmdc.201700568

Alternative Titles